Identification of potential tubulin polymerization inhibitors by 3D-QSAR, molecular docking and molecular dynamics
نویسندگان
چکیده
منابع مشابه
Identification of potential tubulin polymerization inhibitors by 3D-QSAR, molecular docking and molecular dynamics
Combretastatin A-4 (CA-4) is one of the most potent tubulin polymerization inhibitors. In this paper, the identification of some new CA-4 analogues as potential tubulin polymerization inhibitors is performed by combination of molecular modeling techniques including 3D-QSAR, molecular docking and molecular dynamics (MD) simulation. The built 3D-QSAR models show significant statistical quality an...
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2017
ISSN: 2046-2069
DOI: 10.1039/c7ra04314g